(R)-4-hydroxyphenyllactate dehydrogenase
| (R)-4-hydroxyphenyllactate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.222 | ||||||||
| CAS number | 101754-02-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a (R)-4-hydroxyphenyllactate dehydrogenase (EC 1.1.1.222) is an enzyme that catalyzes the chemical reaction
- (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H+
The 3 substrates of this enzyme are (R)-3-(4-hydroxyphenyl)lactate, NAD+, and NADP+, whereas its 4 products are 3-(4-hydroxyphenyl)pyruvate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3-(4-hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase. Other names in common use include (R)-aromatic lactate dehydrogenase, and D-hydrogenase, D-aryllactate. This enzyme participates in tyrosine and phenylalanine catabolism.
References
- Bode R, Lippoldt A, Birnbaum D (1986). "Purification and properties of D-aromatic lactate dehydrogenase an enzyme involved in the catabolism of the aromatic amino acids of Candida maltosa". Biochem. Physiol. Pflanzen. 181: 189&ndash, 198.
- Leelayoova S, Marbury D, Rainey PM, Mackenzie NE, Hall JE (1992). "In vitro tryptophan catabolism by Leishmania donovani donovani promastigotes". J. Protozool. 39 (2): 350–8. doi:10.1111/j.1550-7408.1992.tb01329.x. PMID 1578411.
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