(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase

(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase
Identifiers
EC number 2.4.99.14
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.14, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)2-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->8) glycosidic bond-forming).[1][2][3] This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP

The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes.

References

  1. ↑ Löbau S, Mamat U, Brabetz W, Brade H (November 1995). "Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183". Molecular Microbiology. 18 (3): 391–9. doi:10.1111/j.1365-2958.1995.mmi_18030391.x. PMID 8748024.
  2. ↑ Mamat U, Baumann M, Schmidt G, Brade H (December 1993). "The genus-specific lipopolysaccharide epitope of Chlamydia is assembled in C. psittaci and C. trachomatis by glycosyltransferases of low homology". Molecular Microbiology. 10 (5): 935–41. doi:10.1111/j.1365-2958.1993.tb00965.x. PMID 7523826.
  3. ↑ Belunis CJ, Mdluli KE, Raetz CR, Nano FE (September 1992). "A novel 3-deoxy-D-manno-octulosonic acid transferase from Chlamydia trachomatis required for expression of the genus-specific epitope". The Journal of Biological Chemistry. 267 (26): 18702–7. PMID 1382060.
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