(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase

(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
Identifiers
EC number 2.4.99.13
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.13, KDO transferase, waaA (gene), kdtA (gene), Kdo transferase, 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase.[1][2] This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP

The bifunctional enzyme from Escherichia coli transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA.

See also

  • EC 2.4.99.12, lipid IVA 3-deoxy-D-manno-octulosonic acid transferase

References

  1. ↑ Belunis, C.J.; Raetz, C.R. (1992). "Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli". J. Biol. Chem. 267 (14): 9988–9997. PMID 1577828.
  2. ↑ Lobau, S.; Mamat, U.; Brabetz, W.; Brade, H. (1995). "Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-α-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183". Mol. Microbiol. 18 (3): 391–399. doi:10.1111/j.1365-2958.1995.mmi_18030391.x. PMID 8748024.
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