Ubiquinol oxidase (H+-transporting)

Ubiquinol oxidase (H+-transporting) (EC 7.1.1.3, cytochrome bb3 oxidase, cytochrome bo oxidase, cytochrome bd-I oxidase) is an enzyme with systematic name ubiquinol:O2 oxidoreductase (H+-transporting).[1][2][3][4] This enzyme catalyses the following chemical reaction

2 ubiquinol + O2 + n H+in 2 ubiquinone + 2 H2O + n H+out
Ubiquinol oxidase (H+-transporting)
Identifiers
EC number7.1.1.3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Ubiquinol oxidase contains a dinuclear centre comprising two hemes, or heme and copper.

References

  1. Abramson J, Riistama S, Larsson G, Jasaitis A, Svensson-Ek M, Laakkonen L, Puustinen A, Iwata S, Wikström M (October 2000). "The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site". Nature Structural Biology. 7 (10): 910–7. doi:10.1038/82824. PMID 11017202.
  2. Belevich I, Borisov VB, Zhang J, Yang K, Konstantinov AA, Gennis RB, Verkhovsky MI (March 2005). "Time-resolved electrometric and optical studies on cytochrome bd suggest a mechanism of electron-proton coupling in the di-heme active site". Proceedings of the National Academy of Sciences of the United States of America. 102 (10): 3657–62. doi:10.1073/pnas.0405683102. PMC 553295. PMID 15728392.
  3. Yap LL, Lin MT, Ouyang H, Samoilova RI, Dikanov SA, Gennis RB (December 2010). "The quinone-binding sites of the cytochrome bo3 ubiquinol oxidase from Escherichia coli". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1797 (12): 1924–32. doi:10.1016/j.bbabio.2010.04.011. PMC 2922442. PMID 20416270.
  4. Shepherd M, Sanguinetti G, Cook GM, Poole RK (June 2010). "Compensations for diminished terminal oxidase activity in Escherichia coli: cytochrome bd-II-mediated respiration and glutamate metabolism". The Journal of Biological Chemistry. 285 (24): 18464–72. doi:10.1074/jbc.M110.118448. PMC 2881772. PMID 20392690.
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