UBE2J1

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.[5][6]

UBE2J1
Identifiers
AliasesUBE2J1, HSPC153, HSPC205, HSU93243, NCUBE-1, NCUBE1, UBC6, Ubc6p, CGI-76, UBC6E, ubiquitin conjugating enzyme E2 J1
External IDsOMIM: 616175 MGI: 1926245 HomoloGene: 41090 GeneCards: UBE2J1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q15Start89,326,625 bp[1]
End89,352,722 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51465

56228

Ensembl

ENSG00000198833

ENSMUSG00000028277

UniProt

Q9Y385

Q9JJZ4

RefSeq (mRNA)

NM_016021

NM_019586
NM_001355494

RefSeq (protein)

NP_057105

NP_062532
NP_001342423

Location (UCSC)Chr 6: 89.33 – 89.35 MbChr 4: 33.03 – 33.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000198833 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028277 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lester D, Farquharson C, Russell G, Houston B (Apr 2000). "Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6". Biochem Biophys Res Commun. 269 (2): 474–80. doi:10.1006/bbrc.2000.2302. PMID 10708578.
  6. "Entrez Gene: UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)".

Further reading


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