Tryptophan alpha,beta-oxidase

In enzymology, a tryptophan alpha,beta-oxidase (EC 1.3.3.10) is an enzyme that catalyzes the chemical reaction

L-tryptophan + O2 alpha,beta-didehydrotryptophan + H2O2
tryptophan alpha,beta-oxidase
Identifiers
EC number1.3.3.10
CAS number156859-19-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are L-tryptophan and O2, whereas its two products are alpha,beta-didehydrotryptophan and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is L-tryptophan:oxygen alpha,beta-oxidoreductase. Other names in common use include L-tryptophan 2',3'-oxidase, and L-tryptophan alpha,beta-dehydrogenase. It employs one cofactor, heme.

References

    • Genet R, Denoyelle C, Menez A (1994). "Purification and partial characterization of an amino acid alpha,beta- dehydrogenase, L-tryptophan 2',3'-oxidase from Chromobacterium violaceum". J. Biol. Chem. 269 (27): 18177–84. PMID 8027079.
    • Genet R, Benetti PH, Hammadi A, Menez A (1995). "L-tryptophan 2',3'-oxidase from Chromobacterium violaceum. Substrate specificity and mechanistic implications". J. Biol. Chem. 270 (40): 23540–5. doi:10.1074/jbc.270.40.23540. PMID 7559518.


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