Triphosphoribosyl-dephospho-CoA synthase

In enzymology, a triphosphoribosyl-dephospho-CoA synthase (EC 2.7.8.25) is an enzyme that catalyzes the chemical reaction

ATP + 3-dephospho-CoA 2'-(5"-triphosphoribosyl)-3'-dephospho-CoA + adenine
triphosphoribosyl-dephospho-CoA synthase
Identifiers
EC number2.7.8.25
CAS number313345-38-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are ATP and 3-dephospho-CoA, whereas its two products are 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA and adenine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is ATP:3-dephospho-CoA 5"-triphosphoribosyltransferase. Other names in common use include 2'-(5"-triphosphoribosyl)-3-dephospho-CoA synthase, ATP:dephospho-CoA 5-triphosphoribosyl transferase, and CitG. This enzyme participates in two-component system - general.

References

    • Schneider K, Dimroth P, Bott M (2000). "Biosynthesis of the prosthetic group of citrate lyase". Biochemistry. 39 (31): 9438–50. doi:10.1021/bi000401r. PMID 10924139.
    • Schneider K, Dimroth P, Bott M (2000). "Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group". FEBS Lett. 483 (2–3): 165–8. doi:10.1016/S0014-5793(00)02105-0. PMID 11042274.


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