PRIM2

DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.[5][6]

PRIM2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRIM2, PRIM2A, p58, primase (DNA) subunit 2, DNA primase subunit 2
External IDsOMIM: 176636 MGI: 97758 HomoloGene: 731 GeneCards: PRIM2
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p11.2Start57,314,805 bp[1]
End57,646,850 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5558

19076

Ensembl

ENSG00000146143

ENSMUSG00000026134

UniProt

P49643

P33610

RefSeq (mRNA)

NM_000947
NM_001282487
NM_001282488

NM_008922

RefSeq (protein)

NP_000938
NP_001269416
NP_001269417

NP_032948

Location (UCSC)Chr 6: 57.31 – 57.65 MbChr 1: 33.45 – 33.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000146143 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026134 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics. 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050.
  6. "Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa".

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA primase large subunit (PRIM2)


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