Traditional serrated adenoma

Traditional serrated adenomas (TSA) is a premalignant type of polyp found in the colon, often in the distal colon (sigmoid, rectum). TSAs are a type of serrated polyp, and may occur sporadically or as a part of serrated polyposis syndrome. TSAs are relatively rare, accounting for <1% of all colon polyps.[1][2] Usually, TSAs are found in the distal colon and are usually less than 10 mm in size.[1]

Traditional serrated adenomas
Traditional serrated adenoma with intermediate magnification, showing serrated crypts and cytologic atypia (H&E stain).
SpecialtyGastroenterology
SymptomsAsymptomatic
ComplicationsColorectal cancer
Usual onset>50 years of age
Diagnostic methodColonoscopy
TreatmentPolypectomy
Frequency<1% of all colon polyps

Epidemiology

Usually found in individuals over the age of 50 years, TSAs affect men and women equally.[1]

References

  1. McCarthy, AJ; Serra, S; Chetty, R (2019). "Traditional serrated adenoma: an overview of pathology and emphasis on molecular pathogenesis". BMJ open gastroenterology. 6 (1): e000317. doi:10.1136/bmjgast-2019-000317. PMID 31413858.
  2. Kalimuthu, Sangeetha N.; Chelliah, Adeline; Chetty, Runjan (15 December 2016). "From traditional serrated adenoma to tubulovillous adenoma and beyond". World Journal of Gastrointestinal Oncology. 8 (12): 805–809. doi:10.4251/wjgo.v8.i12.805. ISSN 1948-5204. Retrieved 24 June 2020.
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