Tetrachloroethene reductive dehalogenase

In enzymology, a tetrachloroethene reductive dehalogenase (EC 1.97.1.8) is an enzyme that catalyzes the chemical reaction.[1][2] This is a member of reductive dehalogenase enzyme family.

trichloroethene + chloride + acceptor tetrachloroethene + reduced acceptor
tetrachloroethene reductive dehalogenase
Identifiers
EC number1.97.1.8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 3 substrates of this enzyme are trichloroethene, chloride, and acceptor, whereas its two products are tetrachloroethene and reduced acceptor.

This enzyme belongs to the family of oxidoreductases. The systematic name of this enzyme class is acceptor:trichloroethene oxidoreductase (chlorinating). This enzyme is also called tetrachloroethene reductase. This enzyme participates in tetrachloroethene degradation.

Note that the physiologically relevant reaction actually occurs in the reverse direction from that shown above. In other words, in the bacterial species where this enzyme is found, tetrachloroethene is reductively dechlorinated to trichloroethene and chloride.

This enzyme is one member of a family of enzymes including trichloroethene dehalogenase and vinyl chloride dehalogenase. The other members of this family do not have their own EC numbers at present.

Reductive dehalogenases are key enzymes for anaerobic respiratory process, termed organohalide respiration.

References

  1. Jugder BE, Ertan H, Lee M, Manefield M, Marquis CP (October 2015). "Reductive Dehalogenases Come of Age in Biological Destruction of Organohalides". Trends in Biotechnology. 33 (10): 595–610. doi:10.1016/j.tibtech.2015.07.004. PMID 26409778.
  2. Jugder BE, Ertan H, Bohl S, Lee M, Marquis CP, Manefield M (2016). "Organohalide Respiring Bacteria and Reductive Dehalogenases: Key Tools in Organohalide Bioremediation". Frontiers in Microbiology. 7: 249. doi:10.3389/fmicb.2016.00249. PMC 4771760. PMID 26973626.

Further reading


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