Table of volume of distribution for drugs
This is a table of volume of distribution (Vd) for various medication. For comparison, those with a Vd L/kg body weight of less than 0.2 are mainly distributed in blood plasma, 0.2-0.7 mostly in the extracellular fluid and those with more than 0.7 are distributed throughout total body water.
| Medication | Vd L/kg body weight |
|---|---|
| heparin | 0.05-0.1[1] |
| insulin | 0.05-0.1[1] |
| warfarin | 0.1-0.2[1] |
| sulfamethoxazole | 0.1-0.2[1] |
| glibenclamide | 0.1-0.2[1] |
| atenolol | 0.1-0.2[1] |
| NXY-059 | 0.1-0.2[2] |
| tubocurarine | 0.2-0.4[1] |
| theophylline | 0.4-0.7[1] |
| ethanol | 0.7-0.9[1] |
| neostigmine | 0.7-0.9[1] |
| phenytoin | 0.7-0.9[1] |
| methotrexate | 1-2[1] |
| indometacin | 1-2[1] |
| paracetamol | 1-2[1] |
| diazepam | 1-2[1] |
| lidocaine | 1-2[1] |
| glyceryl nitrate | 2-5[1] |
| morphine | 2-5[1] |
| propranolol | 2-5[1] |
| digoxin | 2-5[1] |
| chlorpromazine | 2-5[1] |
| nortriptyline | 2-5[1] |
| chloroquine | 200[2] |
References & footnotes
- Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 103
- Estimated with a body weight of 70 kg.
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