TRNA-guanine15 transglycosylase

TRNA-guanine15 transglycosylase (EC 2.4.2.48, tRNA transglycosylase, transfer ribonucleate glycosyltransferase, tRNA guanine15 transglycosidase, TGT, transfer ribonucleic acid guanine15 transglycosylase) is an enzyme with systematic name tRNA-guanine15:7-cyano-7-carbaguanine tRNA-D-ribosyltransferase.[1] This enzyme catalyses the following chemical reaction

guanine15 in tRNA + 7-cyano-7-carbaguanine 7-cyano-7-carbaguanine15 in tRNA + guanine
TRNA-guanine15 transglycosylase
Identifiers
EC number2.4.2.48
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Archaeal tRNAs contain the modified nucleoside archaeosine at position 15.

References

  1. Bai Y, Fox DT, Lacy JA, Van Lanen SG, Iwata-Reuyl D (September 2000). "Hypermodification of tRNA in Thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii". The Journal of Biological Chemistry. 275 (37): 28731–8. doi:10.1074/jbc.M002174200. PMID 10862614.
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