TRNA-dihydrouridine20a/20b synthase (NAD(P)+)

TRNA-dihydrouridine20a/20b synthase (NAD(P)+) (EC 1.3.1.90, Dus4p) is an enzyme with systematic name tRNA-5,6-dihydrouracil20a/20b:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(1) 5,6-dihydrouracil20a in tRNA + NAD(P)+ uracil20a in tRNA + NAD(P)H + H+
(2) 5,6-dihydrouracil20b in tRNA + NAD(P)+ uracil20b in tRNA + NAD(P)H + H+
TRNA-dihydrouridine20a/20b synthase (NAD(P)+)
Identifiers
EC number1.3.1.90
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA.

References

  1. Xing F, Hiley SL, Hughes TR, Phizicky EM (April 2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry. 279 (17): 17850–60. doi:10.1074/jbc.M401221200. PMID 14970222.
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