STAG1

Cohesin subunit SA-1 (SA1) is a protein that in humans is encoded by the STAG1 gene.[5][6] SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.

Structure of SA2 (blue) and RAD21 (green) (PDB 4PK7)
STAG1
Identifiers
AliasesSTAG1, SA1, SCC3A, stromal antigen 1, MRD47
External IDsOMIM: 604358 MGI: 1098658 HomoloGene: 21191 GeneCards: STAG1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q22.3Start136,336,236 bp[1]
End136,752,403 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10274

20842

Ensembl

ENSG00000118007

ENSMUSG00000037286

UniProt

Q8WVM7

Q9D3E6

RefSeq (mRNA)

NM_005862

NM_009282
NM_001357264
NM_001357265

RefSeq (protein)

NP_005853

NP_033308
NP_001344193
NP_001344194

Location (UCSC)Chr 3: 136.34 – 136.75 MbChr 9: 100.6 – 100.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure and Interactions

SA1 is one of three human homologues of the yeast protein Scc3 which is a core subunit of the cohesin complex (the three human paralogues are SA1, SA2 and SA3). SA1 and SA2 are expressed in somatic cells whereas SA3 is the main SA paralogue in meiotic cells. SA1 stably binds to cohesin via the RAD21 subunit and functions as a platform for other regulatory subunits. SA1 has roles in regulating both cohesin loading and release. [6]

References

  1. GRCh38: Ensembl release 89: ENSG00000118007 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037286 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
  6. "Entrez Gene: STAG1 stromal antigen 1".
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