Retinal isomerase
In enzymology, a retinal isomerase (EC 5.2.1.3) is an enzyme that catalyzes the isomerisation of trans Retinal in eye into 11-cis-retinal which is form suitable to bind with protein opsin.
- all-trans-retinal 11-cis-retinal
| retinal isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 5.2.1.3 | ||||||||
| CAS number | 9023-76-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Hence, this enzyme has one substrate, all-trans-retinal, and one product, 11-cis-retinal.
This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is all-trans-retinal 11-cis-trans-isomerase. Other names in common use include retinene isomerase, and retinoid isomerase. This enzyme participates in retinol metabolism.
References
- HUBBARD R (1956). "Retinene isomerase". J. Gen. Physiol. 39 (6): 935–62. doi:10.1085/jgp.39.6.935. PMC 2147571. PMID 13346046.
- Shichi H, Somers RL (1974). "Possible involvement of retinylidene phospholipid in photoisomerization of all-trans-retinal to 11-cis-retinal". J. Biol. Chem. 249 (20): 6570–7. PMID 4472816.
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