RNA uridylyltransferase
In enzymology, a RNA uridylyltransferase (EC 2.7.7.52) is an enzyme that catalyzes the chemical reaction
- UTP + RNAn diphosphate + RNAn+1
| RNA uridylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.7.52 | ||||||||
| CAS number | 78519-53-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are UTP and RNAn, whereas its two products are diphosphate and RNAn+1.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:RNA uridylyltransferase. Other names in common use include terminal uridylyltransferase, and TUT.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 2E5G, 2IKF, 2NOM, 2Q0C, 2Q0D, 2Q0E, 2Q0F, and 2Q0G.
References
- Zabel P, Dorssers L, Wernars K, Van Kammen A (1981). "Terminal uridylyl transferase of Vigna unguiculata: purification and characterization of an enzyme catalyzing the addition of a single UMP residue to the 3'-end of an RNA primer". Nucleic Acids Res. 9 (11): 2433–53. doi:10.1093/nar/9.11.2433. PMC 326863. PMID 6269049.
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