Polyenoic fatty acid isomerase

In enzymology, a polyenoic fatty acid isomerase (EC 5.3.3.13) is an enzyme that catalyzes the chemical reaction

(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate (5Z,7E,9E,14Z,17Z)-icosapentaenoate
Polyenoic fatty acid isomerase
Identifiers
EC number5.3.3.13
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Hence, this enzyme has one substrate, (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate, and one product, (5Z,7E,9E,14Z,17Z)-icosapentaenoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming). Other names in common use include PFI, eicosapentaenoate cis-Delta5,8,11,14,17-eicosapentaenoate, cis-Delta5-trans-Delta7,9-cis-Delta14,17 isomerase, (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,8-isomerase, (incorrect), (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,9-isomerase, and (trans-double-bond-forming).

References

    • Wise ML, Hamberg M, Gerwick WH (1994). "Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina". Biochemistry. 33 (51): 15223–32. doi:10.1021/bi00255a002. PMID 7803384.
    • Wise ML, Soderstrom K, Murray TF, Gerwick WH (1996). "Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid". Experientia. 52 (1): 88–92. doi:10.1007/BF01922423. PMID 8575565.
    • Wise ML, Rossi J, Gerwick WH (1997). "Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina". Biochemistry. 36 (10): 2985–92. doi:10.1021/bi962158v. PMID 9062129.
    • Zheng W, Wise ML, Wyrick A, Metz JG, Yuan L, Gerwick WH (2002). "Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA". Arch. Biochem. Biophys. 401 (1): 11–20. doi:10.1016/S0003-9861(02)00002-4. PMID 12054482.


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