Phytoene desaturase (neurosporene-forming)

Phytoene desaturase (neurosporene-forming) (EC 1.3.99.28, 3-step phytoene desaturase, three-step phytoene desaturase, phytoene desaturase (ambiguous), CrtI (ambiguous)) is an enzyme with systematic name 15-cis-phytoene:acceptor oxidoreductase (neurosporene-forming).[1][2] This enzyme catalyses the following chemical reaction

15-cis-phytoene + 3 acceptor all-trans-neurosporene + 3 reduced acceptor (overall reaction)
(1a) 15-cis-phytoene + acceptor all-trans-phytofluene + reduced acceptor
(1b) all-trans-phytofluene + acceptor all-trans-zeta-carotene + reduced acceptor
(1c) all-trans-zeta-carotene + acceptor all-trans-neurosporene + reduced acceptor
Phytoene desaturase (neurosporene-forming)
Identifiers
EC number1.3.99.28
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is involved in carotenoid biosynthesis.

See also

References
  1. Raisig A, Bartley G, Scolnik P, Sandmann G (March 1996). "Purification in an active state and properties of the 3-step phytoene desaturase from Rhodobacter capsulatus overexpressed in Escherichia coli". Journal of Biochemistry. 119 (3): 559–64. doi:10.1093/oxfordjournals.jbchem.a021278. PMID 8830054.
  2. Wang CW, Liao JC (November 2001). "Alteration of product specificity of Rhodobacter sphaeroides phytoene desaturase by directed evolution". The Journal of Biological Chemistry. 276 (44): 41161–4. doi:10.1074/jbc.M105786200. PMID 11526111.
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