Phloroglucinol reductase
In enzymology, a phloroglucinol reductase (EC 1.3.1.57) is an enzyme that catalyzes the chemical reaction
- dihydrophloroglucinol + NADP+ phloroglucinol + NADPH + H+
| phloroglucinol reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.57 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are dihydrophloroglucinol and NADP+, whereas its 3 products are phloroglucinol, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dihydrophloroglucinol:NADP+ oxidoreductase. This enzyme participates in benzoate degradation via coa ligation.
References
- Haddock JD, Ferry JG (1989). "Purification and properties of phloroglucinol reductase from Eubacterium oxidoreducens G-41". J. Biol. Chem. 264 (8): 4423–7. PMID 2925649.
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