ORC6

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.[5][6]

ORC6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesORC6, ORC6L, origin recognition complex subunit 6
External IDsOMIM: 607213 MGI: 1929285 HomoloGene: 8635 GeneCards: ORC6
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q11.2Start46,689,643 bp[1]
End46,698,394 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23594

56452

Ensembl

ENSG00000091651

ENSMUSG00000031697

UniProt

Q9Y5N6

Q9WUJ8

RefSeq (mRNA)

NM_014321

NM_001163791
NM_019716

RefSeq (protein)

NP_055136

n/a

Location (UCSC)Chr 16: 46.69 – 46.7 MbChr 8: 85.3 – 85.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Origin recognition complex subunit 6 (ORC6)
Identifiers
SymbolORC6
PfamPF05460
InterProIPR008721

Background

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.

Function

The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and ORC1 are loosely associated with the core complex consisting of ORC2, -3, -4 and -5. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.[6]

Interactions

ORC6 has been shown to interact with MCM5,[7] ORC2,[7][8] Replication protein A1,[7] ORC4,[7] DBF4,[7] ORC3,[7][8] CDC45-related protein,[7] MCM4[7] and Cell division cycle 7-related protein kinase.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000091651 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031697 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dhar SK, Dutta A (Nov 2000). "Identification and characterization of the human ORC6 homolog". J Biol Chem. 275 (45): 34983–8. doi:10.1074/jbc.M006069200. PMID 10945994.
  6. "Entrez Gene: ORC6L origin recognition complex, subunit 6 like (yeast)".
  7. Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. England. 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612.
  8. Vashee, S; Simancek P; Challberg M D; Kelly T J (Jul 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. United States. 276 (28): 26666–73. doi:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Origin recognition complex (ORC6)


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