Nicotinate riboside kinase

Nicotinate riboside kinase (EC 2.7.1.173, ribosylnicotinic acid kinase, nicotinic acid riboside kinase, NRK1) is an enzyme with systematic name ATP:beta-D-ribosylnicotinate 5-phosphotransferase.[1] This enzyme catalyses the following chemical reaction

ATP + beta-D-ribosylnicotinate ADP + nicotinate beta-D-ribonucleotide
Nicotinate riboside kinase
Identifiers
EC number2.7.1.173
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme from yeast and human also acts as EC 2.7.1.22 (ribosylnicotinamide kinase).

References

  1. Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C (October 2007). "Nicotinamide riboside kinase structures reveal new pathways to NAD+". PLoS Biology. 5 (10): e263. doi:10.1371/journal.pbio.0050263. PMC 1994991. PMID 17914902.
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