N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (EC 2.8.2.33, GalNAc4S-6ST, CHST15 (gene)) is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase.[1][2] This enzyme catalyses the following chemical reaction

(1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
(2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
Identifiers
EC number2.8.2.33
CAS number242469-38-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme is activated by divalent cations and reduced glutathione.

Human proteins containing this domain

References
  1. Ito Y, Habuchi O (November 2000). "Purification and characterization of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase from the squid cartilage". The Journal of Biological Chemistry. 275 (44): 34728–36. doi:10.1074/jbc.M909633199. PMID 10871629.
  2. Ohtake S, Ito Y, Fukuta M, Habuchi O (November 2001). "Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene". The Journal of Biological Chemistry. 276 (47): 43894–900. doi:10.1074/jbc.M104922200. PMID 11572857.
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