GALNAC4S-6ST

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene.[5][6][7][8] It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

CHST15
Identifiers
AliasesCHST15, BRAG, GALNAC4S-6ST, carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15, carbohydrate sulfotransferase 15
External IDsOMIM: 608277 MGI: 1924840 HomoloGene: 8908 GeneCards: CHST15
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q26.13Start124,007,668 bp[1]
End124,093,598 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51363

77590

Ensembl

ENSG00000182022

ENSMUSG00000030930

UniProt

Q7LFX5

Q91XQ5

RefSeq (mRNA)

NM_001270764
NM_001270765
NM_014863
NM_015892

NM_029935
NM_001360768

RefSeq (protein)

NP_001257693
NP_001257694
NP_055678
NP_056976

NP_084211
NP_001347697

Location (UCSC)Chr 10: 124.01 – 124.09 MbChr 7: 132.24 – 132.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References
  1. GRCh38: Ensembl release 89: ENSG00000182022 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030930 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. Verkoczy LK, Marsden PA, Berinstein NL (Oct 1998). "hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1)". Eur J Immunol. 28 (9): 2839–53. doi:10.1002/(SICI)1521-4141(199809)28:09<2839::AID-IMMU2839>3.0.CO;2-6. PMID 9754571.
  7. Ohtake S, Ito Y, Fukuta M, Habuchi O (Nov 2001). "Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene". J Biol Chem. 276 (47): 43894–900. doi:10.1074/jbc.M104922200. PMID 11572857.
  8. "Entrez Gene: GALNAC4S-6ST B cell RAG associated protein".

Further reading
  • Inoue H, Otsu K, Suzuki S, Nakanishi Y (1986). "Difference between N-acetylgalactosamine 4-sulfate 6-O-sulfotransferases from human serum and squid cartilage in specificity toward the terminal and interior portion of chondroitin sulfate". J. Biol. Chem. 261 (10): 4470–5. PMID 3082866.
  • Verkoczy LK, Guinn B, Berinstein NL (2000). "Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells". J. Biol. Chem. 275 (28): 20967–79. doi:10.1074/jbc.M001866200. PMID 10749872.
  • Yuki M, Yoshinaga K, Yamakawa H, et al. (2000). "Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer". Oncol. Rep. 7 (6): 1339–42. doi:10.3892/or.7.6.1339. PMID 11032940.
  • Sekiguchi T, Hirose E, Nakashima N, et al. (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.". J. Biol. Chem. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ohtake S, Kimata K, Habuchi O (2003). "A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase". J. Biol. Chem. 278 (40): 38443–52. doi:10.1074/jbc.M306132200. PMID 12874280.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Sawada T, Fujii S, Nakano H, et al. (2005). "Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D-galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D-galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase". Carbohydr. Res. 340 (12): 1983–96. doi:10.1016/j.carres.2005.06.010. PMID 16024005.


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