Mannosylfructose-phosphate synthase

Mannosylfructose-phosphate synthase (EC 2.4.1.246, mannosylfructose-6-phosphate synthase, MFPS) is an enzyme with systematic name GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase.[1] This enzyme catalyses the following chemical reaction

GDP-mannose + D-fructose 6-phosphate GDP + beta-D-fructofuranosyl-alpha-D-mannopyranoside 6F-phosphate
Mannosylfructose-phosphate synthase
Identifiers
EC number2.4.1.246
CAS number92480-04-1 (not distinguished from EC 2.4.1.167)
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires Mg2+ or Mn2+ for activity.

References

  1. Torres LL, Salerno GL (September 2007). "A metabolic pathway leading to mannosylfructose biosynthesis in Agrobacterium tumefaciens uncovers a family of mannosyltransferases". Proceedings of the National Academy of Sciences of the United States of America. 104 (36): 14318–23. doi:10.1073/pnas.0706709104. PMC 1964871. PMID 17728402.
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