MY-5445

MY-5445 is a relatively specific phosphodiesterase 5 inhibitor.[1][2]

MY-5445
Names
IUPAC name
N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.163.900
Properties
C20H14ClN3
Molar mass 331.80 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also
  • Vatalanib — a structurally related angiogenesis inhibitor

References
  1. Nagendran, J; Archer, SL; Soliman, D; Gurtu, V; Moudgil, R; Haromy, A; St. Aubin, C; Webster, L; Rebeyka, IM; Ross, DB; Light, PE; Dyck, JR; Michelakis, ED (17 July 2007). "Phosphodiesterase Type 5 is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility" (PDF). Circulation. 116 (3): 238–48. doi:10.1161/circulationaha.106.655266. PMID 17606845.
  2. Hagiwara, M; Endo, T; Kanayama, T; Hidaka, H (February 1984). "Effect of 1-(3-Chloroanilino)-4-phenylphthalazine (MY-5445), a Specific Inhibitor of Cyclic GMP Phosphodiesterase, on Human Platelet Aggregation". The Journal of Pharmacology and Experimental Therapeutics. 228 (2): 467–71. PMID 6141286.
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