MMP16

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.[5][6]

MMP16
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMMP16, C8orf57, MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP, matrix metallopeptidase 16
External IDsOMIM: 602262 MGI: 1276107 HomoloGene: 55939 GeneCards: MMP16
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q21.3Start88,032,011 bp[1]
End88,328,025 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4325

17389

Ensembl

ENSG00000156103

ENSMUSG00000028226

UniProt

P51512

Q9WTR0

RefSeq (mRNA)

NM_005941
NM_022564
NM_032297

NM_019724
NM_001379518
NM_001379519

RefSeq (protein)

NP_005932

NP_062698
NP_001366447
NP_001366448

Location (UCSC)Chr 8: 88.03 – 88.33 MbChr 4: 17.85 – 18.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000156103 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028226 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Takino T, Sato H, Shinagawa A, Seiki M (Nov 1995). "Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family". J Biol Chem. 270 (39): 23013–20. doi:10.1074/jbc.270.39.23013. PMID 7559440.
  6. "Entrez Gene: MMP16 matrix metallopeptidase 16 (membrane-inserted)".

Further reading

  • The MEROPS online database for peptidases and their inhibitors: M10.016
  • Overview of all the structural information available in the PDB for UniProt: P51512 (Matrix metalloproteinase-16) at the PDBe-KB.


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