L-seryl-tRNASec selenium transferase
In enzymology, a L-seryl-tRNASec selenium transferase (EC 2.9.1.1) is an enzyme that catalyzes the chemical reaction
- L-seryl-tRNASec + selenophosphate L-selenocysteinyl-tRNASec + phosphate
| L-seryl-tRNASec selenium transferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.9.1.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are L-seryl-tRNASec and selenophosphate, whereas its two products are L-selenocysteinyl-tRNASec and phosphate.
This enzyme belongs to the family of transferases, specifically those transferring selenium-containing groups selenotransferases. The systematic name of this enzyme class is selenophosphate:L-seryl-tRNASec selenium transferase. Other names in common use include L-selenocysteinyl-tRNASel synthase, L-selenocysteinyl-tRNASec synthase selenocysteine synthase, cysteinyl-tRNASec-selenium transferase, and cysteinyl-tRNASec-selenium transferase. This enzyme participates in selenoamino acid metabolism. It employs one cofactor, pyridoxal phosphate.
References
- Forchhammer K, Bock A (1991). "Selenocysteine synthase from Escherichia coli. Analysis of the reaction sequence". J. Biol. Chem. 266 (10): 6324–8. PMID 2007585.