Isoquinoline 1-oxidoreductase

In enzymology, an isoquinoline 1-oxidoreductase (EC 1.3.99.16) is an enzyme that catalyzes the chemical reaction

isoquinoline + acceptor + H2O isoquinolin-1(2H)-one + reduced acceptor
isoquinoline 1-oxidoreductase
Identifiers
EC number1.3.99.16
CAS number155948-73-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 3 substrates of this enzyme are isoquinoline, acceptor, and H2O, whereas its two products are isoquinolin-1(2H)-one and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is isoquinoline:acceptor 1-oxidoreductase (hydroxylating).

References

    • Lehmann M, Tshisuaka B, Fetzner S, Roger P, Lingens F (1994). "Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase". J. Biol. Chem. 269 (15): 11254–60. PMID 8157655.
    • Lehmann M, Tshisuaka B, Fetzner S, Lingens F (1995). "Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases". J. Biol. Chem. 270 (24): 14420–9. doi:10.1074/jbc.270.24.14420. PMID 7782304.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.