Inositol-1,3,4-trisphosphate 5/6-kinase
inositol-1,3,4-trisphosphate 5/6-kinase (EC 2.7.1.159, Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase) is an enzyme with systematic name ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- (1) ATP + 1D-myo-inositol 1,3,4-trisphosphate ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
- (2) ATP + 1D-myo-inositol 1,3,4-trisphosphate ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
| inositol-1,3,4-trisphosphate 5/6-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.1.159 | ||||||||
| CAS number | 288307-53-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6).
References
- Wilson MP, Majerus PW (May 1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". The Journal of Biological Chemistry. 271 (20): 11904–10. doi:10.1074/jbc.271.20.11904. PMID 8662638.
- Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW (January 2005). "The pathway for the production of inositol hexakisphosphate in human cells". The Journal of Biological Chemistry. 280 (3): 1911–20. doi:10.1074/jbc.M411528200. PMID 15531582.
- Miller GJ, Wilson MP, Majerus PW, Hurley JH (April 2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase". Molecular Cell. 18 (2): 201–12. doi:10.1016/j.molcel.2005.03.016. PMID 15837423.
External links
- +inositol-1,3,4-trisphosphate+5/6-kinase at the US National Library of Medicine Medical Subject Headings (MeSH)
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