Ifetroban

Ifetroban
Identifiers
	IUPAC name 3-[2-({(1S,2R,3S)-3-[4-(Pentylcarbamoyl)-1,3-oxazol-2-yl]-7-oxabicyclo[2.2.1]hept-2-yl}methyl)phenyl]propanoic acid;
CAS Number	143443-90-7;
PubChem CID	23724921;
ChemSpider	58452;
UNII	E833KT807K;
KEGG	D04500;
ChEMBL	ChEMBL2146062;
CompTox Dashboard (EPA)	DTXSID40869931 ;
Chemical and physical data
Formula	C25H32N2O5
Molar mass	440.540 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(NCCCCC)c1nc(oc1)[C@@H]4C2O[C@@H](CC2)[C@@H]4Cc3ccccc3CCC(=O)O;

Ifetroban is a potent and selective thromboxane receptor antagonist.[1]

Synthesis

Ifetroban synthesis: Drugs Future (c.f. Lednicer book 6).

Dockens RC, Santone KS, Mitroka JG, Morrison RA, Jemal M, Greene DS, Barbhaiya RH (August 2000). "Disposition of radiolabeled ifetroban in rats, dogs, monkeys, and humans" (PDF). Drug Metabolism and Disposition. 28 (8): 973–80. PMID 10901709.

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