Glycineamide ribonucleotide
Glycineamide ribonucleotide (or GAR) is an intermediate in de novo purine biosynthesis.
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| Names | |
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| IUPAC name
[(2R,3S,4R,5R)-5-[(2-Aminoacetyl)amino]-3,4-dihydroxyoxolan-2-yl]methyldihydrogen phosphate | |
| Other names
Glycineamide ribotide, GAR | |
| Identifiers | |
3D model (JSmol) |
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| ChEBI | |
| ChemSpider | |
| MeSH | Glycineamide+ribonucleotide |
PubChem CID |
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CompTox Dashboard (EPA) |
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| Properties | |
| C7H15N2O8P | |
| Molar mass | 286.177 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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| Infobox references | |
It is formed from phosphoribosylamine by the enzyme phosphoribosylamine—glycine ligase. In the next step of purine biosynthesis the enzyme phosphoribosylglycinamide formyltransferase acts on GAR to form phosphoribosyl-N-formylglycineamide (FGAR).
GAR formation is stimulated by luteinizing hormone (LH) and chorionic gonadotropin (HCG) via activation of Glc-6-P-dehydrogenase (EC 1.1.1.49)[1][2]
Synonyms
Several names are associated with GAR:
- 5'-p-Ribosylglycinamide
- 5'-p-Ribosylglycineamide
- 5'-Phosphoribosyl-glycineamide
- 5'-Phosphoribosylglycinamide
- 5'-Phosphoribosylglycineamide
- Glycineamide ribotide
- Glycinamide ribonucleotide
- Glycineamide ribonucleotide
- N(1)-(5-Phospho-D-ribosyl)glycinamide
- N-Glycyl-5-O-phosphono-D-ribofuranosylamine
- N1-(5-phospho-D-ribosyl)glycinamide
References
- "SMPDB: Glycineamideribotide". August 24, 2015.
- "Human Metabolome Database: Glycineamideribotide". August 24, 2015.
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