Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-b-N-acetylgalactosaminyltransferase

Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.175, N-acetylgalactosaminyltransferase II, UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, chondroitin synthase, glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II) is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
Identifiers
EC number2.4.1.175
CAS number96189-40-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is involved in the biosynthesis of chondroitin sulfate.

References
  1. Rohrmann K, Niemann R, Buddecke E (May 1985). "Two N-acetylgalactosaminyltransferase are involved in the biosynthesis of chondroitin sulfate". European Journal of Biochemistry. 148 (3): 463–9. doi:10.1111/j.1432-1033.1985.tb08862.x. PMID 3922754.
  2. Kitagawa H, Uyama T, Sugahara K (October 2001). "Molecular cloning and expression of a human chondroitin synthase". The Journal of Biological Chemistry. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
  3. DeAngelis PL, Padgett-McCue AJ (August 2000). "Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F". The Journal of Biological Chemistry. 275 (31): 24124–9. doi:10.1074/jbc.M003385200. PMID 10818104.
  4. Ninomiya T, Sugiura N, Tawada A, Sugimoto K, Watanabe H, Kimata K (June 2002). "Molecular cloning and characterization of chondroitin polymerase from Escherichia coli strain K4". The Journal of Biological Chemistry. 277 (24): 21567–75. doi:10.1074/jbc.M201719200. PMID 11943778.
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