Gentamicin 2"-nucleotidyltransferase
In enzymology, a gentamicin 2"-nucleotidyltransferase (EC 2.7.7.46) is an enzyme that catalyzes the chemical reaction
- nucleoside triphosphate + gentamicin diphosphate + 2"-nucleotidylgentamicin
| gentamicin 2-nucleotidyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.7.46 | ||||||||
| CAS number | 62213-33-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are nucleoside triphosphate and gentamicin, whereas its two products are diphosphate and 2''-nucleotidylgentamicin.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NTP:gentamicin 2"-nucleotidyltransferase. Other names in common use include gentamicin 2"-adenylyltransferase, aminoglycoside adenylyltransferase, and gentamicin 2"-nucleotidyltransferase.
References
- Angelatou F, Litsas SB, Kontomichalou P (February 1982). "Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa". J. Antibiot. Tokyo. 35 (2): 235–44. doi:10.7164/antibiotics.35.235. PMID 6281224.
- Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H (December 1971). "The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B". J. Antibiot. Tokyo. 24 (12): 913–4. doi:10.7164/antibiotics.24.913. PMID 4946513.
- Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T (December 1971). "Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor". J. Antibiot. Tokyo. 24 (12): 911–2. doi:10.7164/antibiotics.24.911. PMID 4946512.
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