Ganglioside galactosyltransferase

In enzymology, a ganglioside galactosyltransferase (EC 2.4.1.62) is an enzyme that catalyzes the chemical reaction

UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
ganglioside galactosyltransferase
Identifiers
EC number2.4.1.62
CAS number37217-28-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 2 substrates of this enzyme are UDP-galactose and N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine, whereas its 2 products are UDP and D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galac tosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase. Other names in common use include UDP-galactose-ceramide galactosyltransferase, uridine diphosphogalactose-ceramide galactosyltransferase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, uridine diphosphogalactose-GM2 galactosyltransferase, uridine diphosphate D-galactose:glycolipid galactosyltransferase, UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl), galactosyl-glucosyl-ceramide galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, and GM1-synthase. This enzyme participates in glycosphingolipid biosynthesis - ganglioseries and glycan structures - biosynthesis 2.

References

    • Basu S, Kaufman B, Roseman S (1965). "Conversion of Tay–Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase". J. Biol. Chem. 240 (10): 4115–7. PMID 5842076.
    • Yip GB, Dain JA (1970). "The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceram ide galactosyltransferase in rat brain". Biochim. Biophys. Acta. 206 (2): 252–60. doi:10.1016/0005-2744(70)90108-7. PMID 4987145.
    • Yip MC, Dain JA (1970). "Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosy lceram ide galactosyltransferase". Biochem. J. 118 (2): 247–52. PMC 1179110. PMID 5484669.


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