Dibenzothiophene dihydrodiol dehydrogenase
In enzymology, a dibenzothiophene dihydrodiol dehydrogenase (EC 1.3.1.60) is an enzyme that catalyzes the chemical reaction
- cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD+ 1,2-dihydroxydibenzothiophene + NADH + H+
| dibenzothiophene dihydrodiol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.60 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene and NAD+, whereas its 3 products are 1,2-dihydroxydibenzothiophene, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase.
References
- Laborde AL, Gibson DT (1977). "Metabolism of dibenzothiophene by a Beijerinckia species". Appl. Environ. Microbiol. 34 (6): 783–90. PMC 242748. PMID 596875.
- Denome SA, Stanley DC, Olson ES, Young KD (1993). "Metabolism of dibenzothiophene and naphthalene in Pseudomonas strains: complete DNA sequence of an upper naphthalene catabolic pathway". J. Bacteriol. 175 (21): 6890–901. PMC 206814. PMID 8226631.
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