Diacylglycerol ethanolaminephosphotransferase
In enzymology, an ethanolaminephosphotransferase (EC 2.7.8.1) is an enzyme that catalyzes the chemical reaction
- CDP-ethanolamine + 1,2-diacylglycerol CMP + a phosphatidylethanolamine
| ethanolaminephosphotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.7.8.1 | ||||||||
| CAS number | 9026-19-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are CDP-ethanolamine and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylethanolamine.
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase. Other names in common use include EPT, diacylglycerol ethanolaminephosphotransferase, CDPethanolamine diglyceride phosphotransferase, and phosphorylethanolamine-glyceride transferase. This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.
References
- KENNEDY EP, WEISS SB (1956). "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222: 193–214. PMID 13366993.