D-inositol-3-phosphate glycosyltransferase

D-inositol-3-phosphate glycosyltransferase (EC 2.4.1.250, mycothiol glycosyltransferases, MshA) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
D-inositol-3-phosphate glycosyltransferase
Identifiers
EC number2.4.1.250
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme catalyses the first dedicated reaction in the biosynthesis of mycothiol.

References
  1. Newton GL, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y (June 2003). "The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA)". Journal of Bacteriology. 185 (11): 3476–9. doi:10.1128/JB.185.11.3476-3479.2003. PMC 155378. PMID 12754249.
  2. Newton GL, Ta P, Bzymek KP, Fahey RC (November 2006). "Biochemistry of the initial steps of mycothiol biosynthesis". The Journal of Biological Chemistry. 281 (45): 33910–20. doi:10.1074/jbc.M604724200. PMID 16940050.
  3. Vetting MW, Frantom PA, Blanchard JS (June 2008). "Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis". The Journal of Biological Chemistry. 283 (23): 15834–44. doi:10.1074/jbc.M801017200. PMC 2414306. PMID 18390549.
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