Compound 48/80

Compound 48/80 is a polymer produced by the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde.[1] It promotes histamine release,[2] and in biochemical research, compound 48/80 is used to promote mast cell degranulation.[3]

Compound 48/80
Identifiers
RTECS number
  • Gk2402500
UN number 2811
Properties
(C11H15NO)n
Molar mass Variable
50 mg/mL[1]
Hazards
GHS hazard statements
 H301, H311, H331
P261, P280, P301, P310, P330, P302, P352, P312, P304, P340, P312, P403, P233
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. "Compound48/80". Sigma-Aldrich.
  2. A. M. Rothschild (1970). "Mechanisms of histamine release by compound 48/80". Br J Pharmacol. 38 (1): 253–262. doi:10.1111/j.1476-5381.1970.tb10354.x. PMC 1702640. PMID 4189829.
  3. Schemann, Michael; Kugler, Eva Maria; Buhner, Sabine; Eastwood, Christopher; Donovan, Jemma; Jiang, Wen; Grundy, David (2012). "The Mast Cell Degranulator Compound 48/80 Directly Activates Neurons". PLoS ONE. 7 (12): e52104. doi:10.1371/journal.pone.0052104. PMC 3525567. PMID 23272218.



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