Cis-dihydroethylcatechol dehydrogenase
In enzymology, a cis-dihydroethylcatechol dehydrogenase (EC 1.3.1.66) is an enzyme that catalyzes the chemical reaction
- cis-1,2-dihydro-3-ethylcatechol + NAD+ 3-ethylcatechol + NADH + H+
| cis-dihydroethylcatechol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.66 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are cis-1,2-dihydro-3-ethylcatechol and NAD+, whereas its 3 products are 3-ethylcatechol, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase. This enzyme participates in ethylbenzene degradation.
References
- Gibson DT, Gschwendt B, Yeh WK, Kobal VM (1973). "Initial reactions in the oxidation of ethylbenzene by Pseudomonas putida". Biochemistry. 12 (8): 1520–8. doi:10.1021/bi00732a008. PMID 4699984.
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