Chi-Huey Wong

Chi-Huey Wong is a Taiwanese-American biochemist. He is currently the Scripps Family Chair Professor at the Scripps Research Institute[1], California in the Department of Chemistry. He is a member of the United States National Academy of Sciences, won the Wolf Prize in Chemistry and the RSC Robert Robinson Award.[2] and has published more than 700 papers and holds more than 100 patents.[3]

The native form of this personal name is Wong Chi-Huey. This article uses Western name order when mentioning individuals.
Chi-Huey Wong
翁啟惠
Born (1948-08-03) August 3, 1948
Yizhu, Tainan County, Taiwan (now Chiayi County)
NationalityTaiwan
United States
Alma materNational Taiwan University
Massachusetts Institute of Technology
Awards
  • The IUPAC International Carbohydrate Award (1994)
  • The American Chemical Society Harrison Howe Award (1998)
  • The International Enzyme Engineering Award (1999)
  • The American Chemical Society Claude S. Hudson Award (1999)
  • The Presidential Green Chemistry Challenge Award, USA (2000)
  • The American Chemical Society Award for Creative Work in Synthetic Organic Chemistry (2005)
  • The F. A. Cotton Medal for Excellence in Chemical Research (2008)
  • The American Chemical Society Arthur C. Cope Award (2012)
  • The Wolf Prize in Chemistry (2014)
  • Member of the US National Academy of Sciences and the American Academy of Arts and Sciences
Scientific career
FieldsBiochemistry
chemical biology
Institutions

Education

Wong  received his BS and MS in Biochemical Sciences from National Taiwan University in Taipei, followed by his PhD in Chemistry in 1982 at the Massachusetts Institute of Technology under the direction of Professor George M. Whitesides to study the use of enzymes as catalysts in organic synthesis.[4]

Research and Career

Wong continued his postdoctoral research work with George M. Whitesides at Harvard University from 1982 to 1983, then began his independent career at Texas A&M University in the Chemistry Department. During his tenure at Texas A&M University, he went through the ranks including Assistant Professor, Associate Professor, and Professor of Chemistry.

Wong was appointed as the Ernest W. Hahn Chair and Professor of Chemistry at the Scripps Research Institute and while he was a faculty member at Scripps, he also served as head of the Frontier Research Program on Glycotechnology at Riken in Japan[5] and Director of the Genomics Research Center at Academia Sinica[6], and was later appointed by the President of the Republic of China (Taiwan) as the President of Academia Sinica. Now, he is  serving at the Scripps Research Institute as Scripps Family Chair Professor of Chemistry[7].

Wong is best known for his original contributions to glycoscience, especially his development of chemo-enzymatic methods for the practical synthesis of oligosaccharides[8][9][10][11][12] and glycoproteins[13][14][15][16][17] and the hierarchical and programmable one-pot synthesis method for the rapid preparation of a large number of oligosaccharides[18]. The original synthetic methods developed by Wong along with his work on the development of glycan microarrays[19][20][21][22][23][24][25] for the high-throughput analysis of protein-carbohydrate interaction and the design of glycosylation probes[26][27][28] have enabled not only the fundamental study of glycosylation in biology[29][30][31][32][33] but also the clinical development of carbohydrate-based medicines, including vaccines and homogeneous antibodies for the treatment of cancers and infectious diseases.[34][35][36][37][38]

Awards and honors

Wong has received the Arthur C. Cope Award[39] by the American Chemical Society. Additional awards include the Wolf Prize in Chemistry[40],  Royal Society of Chemistry Robert Robinson Award[41], Searle Scholar Award, Presidential Young Investigator Award, IUPAC International Carbohydrate Award, American Chemical Society Harrison Howe Award, American Chemical Society Claude S. Hudson Award, International Enzyme Engineering Award, the United States Presidential Green Chemistry Award, the F.A. Cotton Medal for Excellence[42] in Chemical Research, and the American Chemical Society Award for Creative Work in Synthetic Organic Chemistry.

Memberships

Wong was elected as a member of the Academia Sinica in 1994, the American Academy of Arts and Science in 1996, the United States National Academy of Sciences in 2002, the World Academy of Sciences in 2007, the United States National Academy of Inventors in 2014, and also an Associate Member of the European Molecular Biology Organization in 2010.[43]

Bibliography
  • Enzymes in Synthetic Organic Chemistry. Pergamon Press. 1994. ISBN 9780-0805-0582-4
  • Carbohydrate Based Drug Discovery. Wiley Online Library. 2003. ISBN 9783-5276-0243-8
  • Current Status and New Challenges in Glycoscience. Springer. ISBN 978-4-431-54841-6

Patents

Wong obtained many patents for his inventions. His representative patents include Globo-H and related anti-cancer vaccines with novel glycolipid adjuvants (US9,603,913B2), Glycan arrays on PTFE-like aluminum coated glass slides and related methods (US8,680,020), Methods and compositions for immunization against virus (US8.741,311), Large scale enzymatic synthesis of oligosaccharides (US9,340,812), Methods for modifying human antibodies by glycan engineering (US10, 087,236), Compositions and methods relating to universal glycoforms for enhanced antibody efficacy (US10,023892), Crystal structure of bifunctional transglycosylase PBP1b from E. Coli and inhibitors thereof (US9890111B2)[44], Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants (US-8906832-B2)[45], Antibiotic compositions and related screening methods (US8916540B2)[46], Hirsutella Sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses (US8486914B2)[47], and Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins (US7943330B2).[48]

References
  1. "Chi-Huey Wong | Scripps Research". www.scripps.edu. Retrieved 2019-10-14.
  2. "RSC Robert Robinson Award 2015 Winner". www.rsc.org. Retrieved 2019-10-14.
  3. "Chi-Huey Wong - Google Scholar Citations". scholar.google.com.tw. Retrieved 2019-10-14.
  4. "Dr. Chi-Huey Wong's Personal Webpage". www.genomics.sinica.edu.tw. Retrieved 2019-10-14.
  5. "Third RIKEN-Academia Sinica Joint Conference | RIKEN". www.riken.jp. Retrieved 2019-10-23.
  6. "Dr. Chi-Huey Wong's Personal Webpage". www.genomics.sinica.edu.tw. Retrieved 2019-10-23.
  7. "70th Birthday: Chi‐Huey Wong :: ChemViews Magazine :: ChemistryViews". www.chemistryviews.org. Retrieved 2019-10-23.
  8. Wong, C. (1989-06-09). "Enzymatic catalysts in organic synthesis". Science. 244 (4909): 1145–1152. doi:10.1126/science.2658059. ISSN 0036-8075. PMID 2658059.
  9. Koeller, Kathryn M.; Wong, Chi-Huey (2001). "Enzymes for chemical synthesis". Nature. 409 (6817): 232–240. doi:10.1038/35051706. ISSN 0028-0836. PMID 11196651.
  10. Sears, P. (2001-03-23). "Toward Automated Synthesis of Oligosaccharides and Glycoproteins". Science. 291 (5512): 2344–2350. doi:10.1126/science.1058899. PMID 11269314.
  11. Machajewski, Timothy D.; Wong, Chi-Huey (2000). "The Catalytic Asymmetric Aldol Reaction". Angewandte Chemie International Edition. 39 (8): 1352–1375. doi:10.1002/(sici)1521-3773(20000417)39:8<1352::aid-anie1352>3.0.co;2-j. ISSN 1521-3773. PMID 10777624.
  12. Ichikawa, Yoshitaka; Lin, Ying Chih; Dumas, David P.; Shen, Gwo Jenn; Garcia-Junceda, Eduardo; Williams, Mark A.; Bayer, Robert; Ketcham, Catherine; Walker, Leslie E. (1992-11-01). "Chemical-enzymic synthesis and conformational analysis of sialyl Lewis X and derivatives". Journal of the American Chemical Society. 114 (24): 9283–9298. doi:10.1021/ja00050a007. ISSN 0002-7863.
  13. Koeller, Kathryn M.; Wong, Chi-Huey (2001). "Enzymes for chemical synthesis". Nature. 409 (6817): 232–240. doi:10.1038/35051706. ISSN 0028-0836. PMID 11196651.
  14. Sears, P. (2001-03-23). "Toward Automated Synthesis of Oligosaccharides and Glycoproteins". Science. 291 (5512): 2344–2350. doi:10.1126/science.1058899. PMID 11269314.
  15. Witte, Krista; Sears, Pamela; Martin, Richard; Wong, Chi-Huey (1997-03-01). "Enzymatic Glycoprotein Synthesis: Preparation of Ribonuclease Glycoforms via Enzymatic Glycopeptide Condensation and Glycosylation". Journal of the American Chemical Society. 119 (9): 2114–2118. doi:10.1021/ja961846z. ISSN 0002-7863.
  16. Brik, Ashraf; Ficht, Simon; Yang, Yu-Ying; Wong, Chi-Huey (2006-11-01). "Sugar-Assisted Ligation of N-Linked Glycopeptides with Broad Sequence Tolerance at the Ligation Junction". Journal of the American Chemical Society. 128 (46): 15026–15033. doi:10.1021/ja065601q. ISSN 0002-7863. PMID 17105315.
  17. Payne, Richard J.; Wong, Chi-Huey (2010-01-07). "Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins". Chemical Communications. 46 (1): 21–43. doi:10.1039/B913845E. ISSN 1364-548X. PMID 20024291.
  18. Galan, M. Carmen; Benito-Alifonso, David; Watt, Gregory M. (2011-05-21). "Carbohydrate chemistry in drug discovery". Organic & Biomolecular Chemistry. 9 (10): 3598–3610. doi:10.1039/C0OB01017K. ISSN 1477-0539. PMID 21409288.
  19. Fazio, Fabio; Bryan, Marian C.; Blixt, Ola; Paulson, James C.; Wong, Chi-Huey (2002-12-01). "Synthesis of Sugar Arrays in Microtiter Plate". Journal of the American Chemical Society. 124 (48): 14397–14402. doi:10.1021/ja020887u. ISSN 0002-7863. PMID 12452714.
  20. Blixt, Ola; Head, Steve; Mondala, Tony; Scanlan, Christopher; Huflejt, Margaret E.; Alvarez, Richard; Bryan, Marian C.; Fazio, Fabio; Calarese, Daniel; Stevens, James; Razi, Nahid (2004-12-07). "Printed covalent glycan array for ligand profiling of diverse glycan binding proteins". Proceedings of the National Academy of Sciences. 101 (49): 17033–17038. doi:10.1073/pnas.0407902101. ISSN 0027-8424. PMC 534418. PMID 15563589.
  21. Walker, Laura M.; Huber, Michael; Doores, Katie J.; Falkowska, Emilia; Pejchal, Robert; Julien, Jean-Philippe; Wang, Sheng-Kai; Ramos, Alejandra; Chan-Hui, Po-Ying; Moyle, Matthew; Mitcham, Jennifer L. (2011). "Broad neutralization coverage of HIV by multiple highly potent antibodies". Nature. 477 (7365): 466–470. doi:10.1038/nature10373. ISSN 1476-4687. PMC 3393110. PMID 21849977.
  22. Pejchal, R.; Doores, K. J.; Walker, L. M.; Khayat, R.; Huang, P.-S.; Wang, S.-K.; Stanfield, R. L.; Julien, J.-P.; Ramos, A.; Crispin, M.; Depetris, R. (2011-11-25). "A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield". Science. 334 (6059): 1097–1103. doi:10.1126/science.1213256. ISSN 0036-8075. PMC 3280215. PMID 21998254.
  23. Shivatare, Sachin S.; Chang, Shih-Huang; Tsai, Tsung-I; Tseng, Susan Yu; Shivatare, Vidya S.; Lin, Yih-Shyan; Cheng, Yang-Yu; Ren, Chien-Tai; Lee, Chang-Chun David; Pawar, Sujeet; Tsai, Charng-Sheng (2016). "Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies". Nature Chemistry. 8 (4): 338–346. doi:10.1038/nchem.2463. ISSN 1755-4330. PMC 4806563. PMID 27001729.
  24. Stewart-Jones, Guillaume B.E.; Soto, Cinque; Lemmin, Thomas; Chuang, Gwo-Yu; Druz, Aliaksandr; Kong, Rui; Thomas, Paul V.; Wagh, Kshitij; Zhou, Tongqing; Behrens, Anna-Janina; Bylund, Tatsiana (2016). "Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G". Cell. 165 (4): 813–826. doi:10.1016/j.cell.2016.04.010. PMC 5543418. PMID 27114034.
  25. Shivatare, Vidya S.; Shivatare, Sachin S.; Lee, Chang-Chun David; Liang, Chi-Hui; Liao, Kuo-Shiang; Cheng, Yang-Yu; Saidachary, Gannerla; Wu, Chung-Yi; Lin, Nan-Horng; Kwong, Peter D.; Burton, Dennis R. (2018-04-18). "Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies". Journal of the American Chemical Society. 140 (15): 5202–5210. doi:10.1021/jacs.8b00896. ISSN 0002-7863. PMID 29578688.
  26. Sawa, M.; Hsu, T.-L.; Itoh, T.; Sugiyama, M.; Hanson, S. R.; Vogt, P. K.; Wong, C.-H. (2006-08-15). "Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo". Proceedings of the National Academy of Sciences. 103 (33): 12371–12376. doi:10.1073/pnas.0605418103. ISSN 0027-8424. PMC 1567886. PMID 16895981.
  27. Hsu, Tsui-Ling; Hanson, Sarah R.; Kishikawa, Kuniyuki; Wang, Sheng-Kai; Sawa, Masaaki; Wong, Chi-Huey (2007-02-20). "Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells". Proceedings of the National Academy of Sciences. 104 (8): 2614–2619. doi:10.1073/pnas.0611307104. ISSN 0027-8424. PMC 1815231. PMID 17296930.
  28. Shie, Jiun-Jie; Liu, Ying-Chih; Lee, Yu-Ming; Lim, Carmay; Fang, Jim-Min; Wong, Chi-Huey (2014-07-16). "An Azido-BODIPY Probe for Glycosylation: Initiation of Strong Fluorescence upon Triazole Formation". Journal of the American Chemical Society. 136 (28): 9953–9961. doi:10.1021/ja5010174. ISSN 0002-7863. PMID 24955871.
  29. Hanson, S. R.; Culyba, E. K.; Hsu, T.-L.; Wong, C.-H.; Kelly, J. W.; Powers, E. T. (2009-03-03). "The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability". Proceedings of the National Academy of Sciences. 106 (9): 3131–3136. doi:10.1073/pnas.0810318105. ISSN 0027-8424. PMC 2651298. PMID 19204290.
  30. Huang, Yen-Wen; Yang, Hwai-I; Wu, Ying-Ta; Hsu, Tsui-Ling; Lin, Tzu-Wen; Kelly, Jeffery W.; Wong, Chi-Huey (2017-09-20). "Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency". Journal of the American Chemical Society. 139 (37): 12947–12955. doi:10.1021/jacs.7b03868. ISSN 0002-7863. PMID 28820257.
  31. Krasnova, Larissa; Wong, Chi-Huey (2016-06-02). "Understanding the Chemistry and Biology of Glycosylation with Glycan Synthesis". Annual Review of Biochemistry. 85 (1): 599–630. doi:10.1146/annurev-biochem-060614-034420. ISSN 0066-4154. PMID 27145845.
  32. Krasnova, Larissa; Wong, Chi-Huey (2019-03-06). "Oligosaccharide Synthesis and Translational Innovation". Journal of the American Chemical Society. 141 (9): 3735–3754. doi:10.1021/jacs.8b11005. ISSN 0002-7863. PMC 6538563. PMID 30716271.
  33. Chuang, Po-Kai; Hsiao, Michael; Hsu, Tsui-Ling; Chang, Chuan-Fa; Wu, Chung-Yi; Chen, Bo-Rui; Huang, Han-Wen; Liao, Kuo-Shiang; Chen, Chen-Chun; Chen, Chi-Long; Yang, Shun-Min (2019-02-26). "Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer". Proceedings of the National Academy of Sciences. 116 (9): 3518–3523. doi:10.1073/pnas.1816946116. ISSN 0027-8424. PMC 6397564. PMID 30808745.
  34. Sears, P. (2001-03-23). "Toward Automated Synthesis of Oligosaccharides and Glycoproteins". Science. 291 (5512): 2344–2350. doi:10.1126/science.1058899. PMID 11269314.
  35. Tseng, Yung-Chieh; Wu, Chia-Yu; Liu, Ming-Liang; Chen, Ting-Hua; Chiang, Wan-Ling; Yu, Yueh-Hsiang; Jan, Jia-Tsrong; Lin, Kuo-I; Wong, Chi-Huey; Ma, Che (2019-03-05). "Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections". Proceedings of the National Academy of Sciences. 116 (10): 4200–4205. doi:10.1073/pnas.1819197116. ISSN 0027-8424. PMC 6410868. PMID 30782805.
  36. Lin, Chin-Wei; Tsai, Ming-Hung; Li, Shiou-Ting; Tsai, Tsung-I.; Chu, Kuo-Ching; Liu, Ying-Chih; Lai, Meng-Yu; Wu, Chia-Yu; Tseng, Yung-Chieh; Shivatare, Sachin S.; Wang, Chia-Hung (2015-08-25). "A common glycan structure on immunoglobulin G for enhancement of effector functions". Proceedings of the National Academy of Sciences of the United States of America. 112 (34): 10611–10616. doi:10.1073/pnas.1513456112. ISSN 1091-6490. PMC 4553773. PMID 26253764.
  37. Lo, Hong-Jay; Krasnova, Larissa; Dey, Supriya; Cheng, Ting; Liu, Haitian; Tsai, Tsung-I; Wu, Kevin Binchia; Wu, Chung-Yi; Wong, Chi-Huey (2019-04-24). "Synthesis of Sialidase-Resistant Oligosaccharide and Antibody Glycoform Containing α2,6-Linked 3Fax-Neu5Ac". Journal of the American Chemical Society. 141 (16): 6484–6488. doi:10.1021/jacs.9b01991. ISSN 0002-7863. PMID 30969765.
  38. Kinjo, Yuki; Wu, Douglass; Kim, Gisen; Xing, Guo-Wen; Poles, Michael A.; Ho, David D.; Tsuji, Moriya; Kawahara, Kazuyoshi; Wong, Chi-Huey; Kronenberg, Mitchell (2005). "Recognition of bacterial glycosphingolipids by natural killer T cells". Nature. 434 (7032): 520–525. doi:10.1038/nature03407. ISSN 1476-4687. PMID 15791257.
  39. "Academia Sinica President Chi-Huey Wong To Receive 2012 Arthur C. Cope Award". Asian Scientist Magazine. 2011-09-08. Retrieved 2019-10-23.
  40. "פרופ' צ'י-ווי וונג". www.wolffund.org.il. Retrieved 2019-10-23.
  41. "Academia Sinica President Chi-Huey Wong Receives 2015 Robert Robinson Award". www.genomics.sinica.edu.tw. Retrieved 2019-10-23.
  42. "Cotten Medal".
  43. User, Super. "EMBO recognizes 63 researchers for advances in life sciences". EMBO. Retrieved 2019-10-23.
  44. , "Crystal structure of bifunctional transglycosylase PBP1b from E. coli and inhibitors thereof", issued 2015-12-04
  45. "Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants - Dimensions". app.dimensions.ai. Retrieved 2019-10-23.
  46. , "Antibiotic compositions and related screening methods", issued 2009-01-15
  47. , "Hirsutella sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses", issued 2010-03-30
  48. , "Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins", issued 2008-03-24
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