Cellobiose phosphorylase

In enzymology, a cellobiose phosphorylase (EC 2.4.1.20) is an enzyme that catalyzes the chemical reaction

cellobiose + phosphate alpha-D-glucose 1-phosphate + D-glucose
cellobiose phosphorylase
Cellobiose phosphorylase dimer, Cellulomonas uda
Identifiers
EC number2.4.1.20
CAS number9030-20-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are cellobiose and phosphate, whereas its two products are alpha-D-glucose 1-phosphate and D-glucose.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is cellobiose:phosphate alpha-D-glucosyltransferase. This enzyme participates in starch and sucrose metabolism.

Structural studies

As of late 2006, two structures have been solved for this class of enzymes, with PDB accession codes 2CQS and 2CQT.

References

    • Alexander JK (June 1968). "Purification and specificity of cellobiose phosphorylase from Clostridium thermocellum". The Journal of Biological Chemistry. 243 (11): 2899–904. PMID 5653182.
    • Ayers WA (November 1959). "Phosphorolysis and synthesis of cellobiose by cell extracts from Ruminococcus flavefaciens". The Journal of Biological Chemistry. 234: 2819–22. PMID 13795349.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.