Bone morphogenetic protein 6

Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene.[5][6][7]

BMP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QCW, 2R52, 2R53
Identifiers
Aliases	BMP6, VGR, VGR1, bone morphogenetic protein 6
External IDs	OMIM: 112266 MGI: 88182 HomoloGene: 1300 GeneCards: BMP6
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p24.3 Start 7,726,099 bp[1] End 7,881,728 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A3.3|13 18.15 cM Start 38,345,107 bp[2] End 38,500,302 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine activity • BMP receptor binding • protein heterodimerization activity • transforming growth factor beta receptor binding • growth factor activity Cellular component • cytoplasm • extracellular region • extracellular • vesicle Biological process • eye development • regulation of apoptotic process • skeletal system development • cell differentiation • cellular response to iron ion • male genitalia development • positive regulation of aldosterone secretion • positive regulation of endothelial cell differentiation • regulation of MAPK cascade • positive regulation of endothelial cell proliferation • SMAD protein signal transduction • positive regulation of aldosterone biosynthetic process • response to retinoic acid • ossification • kidney development • positive regulation of bone mineralization • positive regulation of epithelial cell proliferation • positive regulation of pathway-restricted SMAD protein phosphorylation • cellular response to BMP stimulus • response to magnesium ion • response to glucocorticoid • negative regulation of transcription from RNA polymerase II promoter • endochondral ossification • response to activity • BMP signaling pathway • response to iron ion • positive regulation of lipopolysaccharide-mediated signaling pathway • multicellular organismal iron ion homeostasis • multicellular organism development • cellular response to mechanical stimulus • cartilage development • positive regulation of osteoblast differentiation • positive regulation of chondrocyte differentiation • osteoblast differentiation • immune response • positive regulation of neuron differentiation • positive regulation of protein secretion • inflammatory response • type B pancreatic cell development • positive regulation of transcription from RNA polymerase II promoter • positive regulation of SMAD protein import into nucleus • cellular iron ion homeostasis • regulation of receptor activity • positive regulation of cell proliferation • cell development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	654	12161
Ensembl	ENSG00000153162	ENSMUSG00000039004
UniProt	P22004	P20722
RefSeq (mRNA)	NM_001718	NM_007556
RefSeq (protein)	NP_001709	NP_031582
Location (UCSC)	Chr 6: 7.73 – 7.88 Mb	Chr 13: 38.35 – 38.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells.

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. As of April 2009, an additional function of BMP6 has been identified as described in Nature Genetics April; 41 [4]:386-8. BMP6 is the key regulator of hepcidin, the small peptide secreted by the liver which is the major regulator of iron metabolism in mammals.

[7]