Bile-acid 7alpha-dehydroxylase

Bile-acid 7alpha-dehydroxylase (EC 1.17.99.5, cholate 7alpha-dehydroxylase, 7alpha-dehydroxylase, bile acid 7-dehydroxylase) is an enzyme with systematic name deoxycholate:NAD+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) deoxycholate + NAD+ + H2O cholate + NADH + H+
(2) lithocholate + NAD+ + H2O chenodeoxycholate + NADH + H+
Bile-acid 7alpha-dehydroxylase
Identifiers
EC number1.17.99.5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Bile-acid 7alpha-dehydroxylase is highly specific for bile acid substrates.

References

  1. White BA, Cacciapuoti AF, Fricke RJ, Whitehead TR, Mosbach EH, Hylemon PB (August 1981). "Cofactor requiremets for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708". Journal of Lipid Research. 22 (6): 891–8. PMID 7276750.
  2. White BA, Paone DA, Cacciapuoti AF, Fricke RJ, Mosbach EH, Hylemon PB (January 1983). "Regulation of bile acid 7-dehydroxylase activity by NAD+ and NADH in cell extracts of Eubacterium species V.P.I. 12708". Journal of Lipid Research. 24 (1): 20–7. PMID 6833878.
  3. Coleman JP, White WB, Hylemon PB (April 1987). "Molecular cloning of bile acid 7-dehydroxylase from Eubacterium sp. strain VPI 12708". Journal of Bacteriology. 169 (4): 1516–21. PMC 211977. PMID 3549693.
  4. Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
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