Atrolysin A
Atrolysin A (EC 3.4.24.1, Crotalus atrox metalloendopeptidase a, hemorrhagic toxin a, Crotalus atrox alpha-proteinase, Crotalus atrox proteinase, bothropasin) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Cleavage of Asn3-Gln, His5-Leu, His10-Leu, Ala14-Leu and Tyr16-Leu in insulin B chain; removes C-terminal Leu from small peptides
| Atrolysin A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.1 | ||||||||
| CAS number | 37288-82-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This endopeptidase is one of six hemorrhagic toxins in the venom of western diamondback rattlesnake.
References
- Bjarnason JB, Tu AT (August 1978). "Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry. 17 (16): 3395–404. doi:10.1021/bi00609a033. PMID 210790.
- Mori N, Nikai T, Sugihara H, Tu AT (February 1987). "Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom". Archives of Biochemistry and Biophysics. 253 (1): 108–21. doi:10.1016/0003-9861(87)90643-6. PMID 2949699.
- Bjarnason JB, Hamilton D, Fox JW (May 1988). "Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom". Biological Chemistry Hoppe-Seyler. 369 Suppl: 121–9. PMID 3060135.
- Bjarnason JB, Fox JW (1989). "Hemorrhagic toxins from snake venoms". J. Toxicol. Toxin Rev. 7: 121–209. doi:10.3109/15569548809059729.
External links
- Atrolysin+A at the US National Library of Medicine Medical Subject Headings (MeSH)
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