Aryl-acylamidase
In enzymology, an aryl-acylamidase (EC 3.5.1.13) is an enzyme that catalyzes the chemical reaction
- an anilide + H2O a carboxylate + aniline
| aryl-acylamidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.1.13 | ||||||||
| CAS number | 9025-18-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are anilide and H2O, whereas its two products are carboxylate and aniline.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is aryl-acylamide amidohydrolase. Other names in common use include AAA-1, AAA-2, brain acetylcholinesterase (is associated with AAA-2), and pseudocholinesterase (associated with arylacylamidase).
References
- Nimmo-Smith RH (May 1960). "Aromatic N-deacylation by chick-kidney mitochondria". The Biochemical Journal. 75 (2): 284–93. PMC 1204423. PMID 14427286.
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