Amlodipine/benazepril
Amlodipine/benazepril, marketed as Lotrel among others, is a medication used to treat high blood pressure.[1] It is a combination of amlodipine, a calcium channel blocker and benazepril, an angiotensin converting enzyme inhibitor.[1] It may be used if a single agent is not sufficient.[1] It is taken by mouth.[1]
Combination of | |
---|---|
Amlodipine | Calcium channel blocker |
Benazepril | ACE inhibitor |
Clinical data | |
Trade names | Lotrel |
AHFS/Drugs.com | Professional Drug Facts |
License data | |
Pregnancy category |
|
Routes of administration | By mouth |
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
CAS Number | |
PubChem CID | |
ChemSpider | |
KEGG | |
CompTox Dashboard (EPA) | |
|
Common side effects include cough, dizziness, and swelling.[1] Serious side effects may include angioedema, myocardial infarction, high blood potassium, liver problems, and low blood pressure.[1] Use in pregnancy is not recommended.[1] Amlodipine works by increasing the size of arteries while benazepril works by decreasing renin-angiotensin-aldosterone system activity.[1]
The combination was approved for medical use in the United States in 1995.[2] It is available as a generic medication.[3] A month supply in the United States has a wholesale cost of about US$4.50.[4] In 2017, it was the 160th most commonly prescribed medication in the United States, with more than three million prescriptions.[5][6]
References
- "DailyMed - Amlodipine besylate and benazepril hydrochloride- amlodipine besylate and benazepril hydrochloride capsule". dailymed.nlm.nih.gov. Retrieved 10 March 2019.
- "Amlodipine and benazepril Uses, Side Effects & Warnings". Drugs.com. Retrieved 10 March 2019.
- Bope, Edward T.; Kellerman, Rick D. (2016). Conn's Current Therapy 2017 E-Book. Elsevier Health Sciences. p. 124. ISBN 9780323443357.
- "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
- "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
- "Amlodipine Besylate; Benazepril Hydrochloride - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
- Faulkner, MA; Hilleman, DE (January 2001). "Amlodipine/benazepril: fixed dose combination therapy for hypertension". Expert Opinion on Pharmacotherapy. 2 (1): 165–78. doi:10.1517/14656566.2.1.165. PMID 11336577.
External links
- "Amlodipine mixture with Benazepril". Drug Information Portal. U.S. National Library of Medicine.