Adenosylcobinamide-GDP ribazoletransferase

Adenosylcobinamide-GDP ribazoletransferase (EC 2.7.8.26, CobS, cobalamin synthase, cobalamin-5'-phosphate synthase, cobalamin (5'-phosphate) synthase) is an enzyme with systematic name adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase.[1][2][3] This enzyme catalyses the following chemical reaction

(1) adenosylcobinamide-GDP + alpha-ribazole GMP + adenosylcobalamin
(2) adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate GMP + adenosylcobalamin 5'-phosphate
Adenosylcobinamide-GDP ribazoletransferase
Identifiers
EC number2.7.8.26
CAS number137672-85-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in bacteria.

See also

References

  1. Maggio-Hall LA, Escalante-Semerena JC (October 1999). "In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes". Proceedings of the National Academy of Sciences of the United States of America. 96 (21): 11798–803. doi:10.1073/pnas.96.21.11798. PMC 18366. PMID 10518530.
  2. Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (August 2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Natural Product Reports. 19 (4): 390–412. doi:10.1039/b108967f. PMID 12195810.
  3. Cameron B, Blanche F, Rouyez MC, Bisch D, Famechon A, Couder M, Cauchois L, Thibaut D, Debussche L, Crouzet J (October 1991). "Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5'-phosphate) synthase". Journal of Bacteriology. 173 (19): 6066–73. doi:10.1128/jb.173.19.6066-6073.1991. PMC 208353. PMID 1917841.
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