Acylglycerone-phosphate reductase
In enzymology, an acylglycerone-phosphate reductase (EC 1.1.1.101) is an enzyme that catalyzes the chemical reaction
- 1-palmitoylglycerol 3-phosphate + NADP+ palmitoylglycerone phosphate + NADPH + H+
| acylglycerone-phosphate reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.101 | ||||||||
| CAS number | 37250-35-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 1-palmitoylglycerol 3-phosphate and NADP+, whereas its 3 products are palmitoylglycerone phosphate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase. Other names in common use include palmitoyldihydroxyacetone-phosphate reductase, palmitoyl dihydroxyacetone phosphate reductase, palmitoyl-dihydroxyacetone-phosphate reductase, acyldihydroxyacetone phosphate reductase, and palmitoyl dihydroxyacetone phosphate reductase. This enzyme participates in glycerophospholipid and ether lipid metabolism.
References
- LaBelle EF, Hajra AK (September 1972). "Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides". The Journal of Biological Chemistry. 247 (18): 5825–34. PMID 4403490.