ATP8B3

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.[5]

ATP8B3
Identifiers
AliasesATP8B3, ATPIK, ATPase phospholipid transporting 8B3
External IDsOMIM: 605866 MGI: 1914581 HomoloGene: 19034 GeneCards: ATP8B3
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start1,782,075 bp[1]
End1,812,276 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

148229

67331

Ensembl

ENSG00000130270

ENSMUSG00000003341

UniProt

O60423

Q6UQ17

RefSeq (mRNA)

NM_001178002
NM_138813

NM_026094

RefSeq (protein)

NP_001171473
NP_620168

NP_080370

Location (UCSC)Chr 19: 1.78 – 1.81 MbChr 10: 80.52 – 80.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[5]

References
  1. GRCh38: Ensembl release 89: ENSG00000130270 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003341 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ATPase, aminophospholipid transporter, class I, type 8B, member 3". Retrieved 2011-10-22.

Further reading
  • Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (November 1999). "Differential expression of putative transbilayer amphipath transporters". Physiological Genomics. 1 (3): 139–50. doi:10.1152/physiolgenomics.1999.1.3.139. PMID 11015572.
  • Harris MJ, Arias IM (July 2003). "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1633 (2): 127–31. doi:10.1016/S1388-1981(03)00107-0. PMID 12880872.
  • Fries AS, Svendsen O (January 1978). "Studies on Tyzzer's disease in rats". Laboratory Animals. 12 (1): 1–4. doi:10.1258/002367778780953297. PMID 146761.
  • Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M (May 2009). "Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 106 (18): 7501–6. Bibcode:2009PNAS..106.7501S. doi:10.1073/pnas.0813386106. PMC 2678639. PMID 19416921.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.