(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
(KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.13, KDO transferase, waaA (gene), kdtA (gene), Kdo transferase, 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase.[1][2] This enzyme catalyses the following chemical reaction
- alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP
| (KDO)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.99.13 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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The bifunctional enzyme from Escherichia coli transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA.
See also
- EC 2.4.99.12, lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
References
- Belunis CJ, Raetz CR (May 1992). "Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli". The Journal of Biological Chemistry. 267 (14): 9988–97. PMID 1577828.
- Löbau S, Mamat U, Brabetz W, Brade H (November 1995). "Molecular cloning, sequence analysis, and functional characterization of the lipopolysaccharide biosynthetic gene kdtA encoding 3-deoxy-alpha-D-manno-octulosonic acid transferase of Chlamydia pneumoniae strain TW-183". Molecular Microbiology. 18 (3): 391–9. doi:10.1111/j.1365-2958.1995.mmi_18030391.x. PMID 8748024.
External links
- (KDO)-lipid+IVA+3-deoxy-D-manno-octulosonic+acid+transferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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